In Japan, Esther Formula entered Qoo10 and became the top-ranking brand in the "Mega Waribiki" beauty supplement category
Adequate hydrationat least 80 ounces of water dailybecomes non-negotiable on semaglutide, as it directly prevents constipation and supports kidney function during rapid weight loss
In addition to gastroparesis (severely slowed digestion), the FDA has highlighted risks of intestinal obstruction (ileus) and severe constipation, including fecal impaction (hardened stool that stays stuck in the rectum)
Its principal evidence comes from the SURMOUNT program for weight management, published in The New England Journal of Medicine in 2022, and SURMOUNT-OSA for obstructive sleep apnea, published in NEJM in 2024
In particular, concerns about weight gain and control of blood glucose appear to have driven the difference between outcomes for orally administered semaglutide 7 and 14 mg compared with dulaglutide 0.75 mg (Table S1)
doi: 10.3390/ijms24032959